Hold onto your scrubs because we're diving deep into the dramatic world of Dr. Alex Karev's love life. As one of the longest-standing residents of Grey Sloan Memorial, Alex has seen his fair share of heartbreaks, triumphs, and everything in between. From the early days of Seattle Grace to the present, Alex's romantic history reads like a soap opera in its own right. Today, he's found happiness with Dr. Jo Wilson, but it wasn't always smooth sailing. Let's take a walk down memory lane and meet all the women who've captured Alex's heart.
Jo Wilson: The On-Again, Off-Again Love Story
Jo Wilson entered Alex's life at Miranda Bailey's wedding in Season 9, and let's just say, the chemistry was instant. Despite their initial spark, their relationship has been anything but simple. Alex admitted his feelings for Jo early on, and the two began dating. In true Grey's Anatomy fashion, their love story took a dramatic turn when Alex proposed at April Kepner’s wedding. However, Jo declined, choosing to continue their relationship without the pressure of marriage. Fast forward to Season 11, Alex proposed again, but Jo hesitated, leading to a temporary split. But, as they say, absence makes the heart grow fonder, and they eventually reunited.

Alex and Jo on Grey’s Anatomy. (Photo Credit: Getty Images)
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Jo's confession about her abusive past and her secret marriage added another layer of complexity to their relationship. When Alex discovered Andrew DeLuca with a drunken Jo, he assumed the worst and lashed out, further complicating things. But Alex's loyalty shone through when he revealed he had found her abusive ex-husband, proving his commitment to Jo's safety. Despite the ups and downs, Jo finally gave Alex another chance, and they're currently back together, navigating their relationship with renewed hope.
Izzie Stevens: The On-Again, Off-Again Love Story
Alex's relationship with Izzie Stevens is a tale of passion, drama, and heartbreak. Their romance began during their days as interns at Seattle Grace, but it wasn't long before Alex's infidelity with nurse Olivia Harper threatened to derail their love. After a rocky reconciliation, Alex's insensitive comments about Izzie's patient, Denny Duquette, led to another breakup. Izzie famously declared, "You're not good enough for me, Alex. You're not good enough for anyone," cutting deep into Alex's pride.
Even after their breakup, Alex couldn't let go of his feelings for Izzie. When Denny passed away, Alex helped Izzie cope with her grief, reigniting old flames. Their whirlwind romance culminated in a Season 5 wedding, but tragedy struck when Izzie's best friend, George O’Malley, died. Heartbroken, Izzie left Alex, and the two eventually divorced. It was a painful end to a once-beautiful love story.
Rebecca Pope (Ava): The Woman With Two Identities
Rebecca Pope, or Ava as she was initially known, entered Alex's life after a ferry accident left her severely injured and disfigured. As Alex cared for her during her recovery, a bond formed between them, blossoming into a romantic relationship. Things took a dramatic turn when Ava discovered her true identity as Rebecca Pope, a married mother. Despite this revelation, their connection remained strong, and Rebecca even claimed she was pregnant with Alex's child.



